Comprehensive molecular characterization of CNS tumors is critical for accurate diagnosis and treatment planning. In this talk, Dr. Matija Snuderl, neuropathologist and Director of Molecular Pathology at NYU Langone Health, presents an integrated genomic–epigenetic workflow using TAPS+, a bisulfite-free sequencing method for direct detection of 5-methylcytosine (5mC) from various samples including FFPE and CSF ctDNA. The approach enables simultaneous profiling of genetic and epigenetic alterations, maximizing insights from limited or degraded material. Dr. Snuderl will share data demonstrating utility for simultaneous detection of genetic drivers and epigenetic classification. This unified workflow is ideally suited for precision oncology applications and advancing our understanding of the epigenomic landscape in CNS tumors.
