This workshop will present how Roche’s sequencing by expansion (SBX) technology can enable Oncology research with its high accuracy and sensitivity. In the first presentation, Dr Edwin Cuppen will present on Hartwig Medical Foundation’s experiences with SBX, including in-depth data analyses of paired tumor-normal Whole-genome sequencing (WGS) and logistics of the workflow which is different from other technologies. WGS is rapidly advancing as an important technique in oncology research, offering a scalable solution for comprehensive genomic profiling and generating rich datasets for future applications in clinical development, translational research, and understanding tumorigenesis. In the second presentation, Dr Mahdi Golkaram will discuss SBX duplex methylation (SBX-DM) sequencing, which improves SNP error correction, enables high-throughput cfDNA WGS, and integrates methylation detection for enhanced MRD signal sensitivity.
