A new day, a better way to see and understand cancer

Disentangling the molecular drivers of cancer progression requires a precise understanding of the somatic alterations that take place at the DNA level during tumor development. These include not only small changes like SNVs and indels, but also structural variants, changes in repetitive elements, differential methylation, chromatin accessibility, and the haplotype context in which these changes occur. Existing methods lack the read length and accuracy needed to characterize these changes, while long read sequencing with PacBio HiFi enables comprehensive profiling of all germline and somatic changes leading to cancer, even for low-input or challenging samples like FFPE.