Case Studies in Solid Tumors I

Co-Moderator (T & E Cmte)(s)

• 

  Brett Baskovich, MD (he/him/his)

  Medical Director
  Pathology
  ThyroSeq Laboratory, Sonic Healthcare
  New York, New York, United States
• EV

  Erica Vormittag-Nocito, MD

  Medical Director, Illinois Central Laboratory
  Advocate Health

Session

Description: Challenging Case Studies are presented by trainees or technologists. They will discuss the case's clinical history, molecular analysis, interesting features, and the proposed diagnosis. Other molecular testing methods, if applicable, will be included in the presentation, including biopsies, gross/microscopic pathology, immunohistochemistry/flow cytometry, and cytogenetic findings.

Session

Objectives:
- Describe the context of a challenging clinical case.
- Discuss the molecular pathology techniques used in the diagnosis of the case.
- Propose a final diagnosis based upon findings and diagnostic evidence.

Presentations:

• 7:00 AM - 7:15 AM EST

  Both DNA Methylation and RNAseq were Necessary to Diagnosis an Intracranial Sarcoma
  

  Case Presenter: Christina Ferrone
• 7:15 AM - 7:30 AM EST

  A Surprise Case of Familial Biparental Hydatidiform Mole
  

  Case Presenter: Samuel E. Harvey, MD PhD (he/him/his) – Johns Hopkins University School of Medicine
• 7:30 AM - 7:45 AM EST

  Detection of MYBL1 Rearrangement as a Diagnostic Hallmark in Diffuse Astrocytoma Through Integrated Copy Number and Structural Variant Calling
  

  Case Presenter: Ege Cubuk, MD (he/him/his) – Baylor College of Medicine, Pathology & Immunology
• 7:45 AM - 8:00 AM EST

  Undifferentiated Epithelioid and Spindle Cell Neoplasm of the Uterus Harboring SMARCA2::CREM fusion: Exploring the Spectrum of the New Entity
  

  Case Presenter: Kanako Okamoto, MD – University of Alabama at Birmingham