Real-world evidence (RWE) from published clinical literature offers a powerful yet underutilized lens into patient outcomes, therapeutic response, and biomarker discovery. This workshop will highlight how literature-based RWE augments traditional real-world data by uncovering patient- and variant-specific insights across thousands of publications. We will demonstrate its value in pharma for optimizing trial design, informing label expansion, and deepening disease understanding, illustrated by oncology case studies. In parallel, we will show how clinicians use expertly curated evidence in the Cancer Knowledgebase (CKB) to identify treatment options and relevant trials. We will cover a number of case studies where we spotlight how integrating curated literature-based RWE—spanning variant evidence, efficacy data, guidelines, patient characteristics, and trial criteria—refines patient stratification and enables more precise therapeutic decisions in precision oncology.
