Recent breakthroughs in informatics are transforming precision oncology research, streamlining interpretation and reporting of NGS data to deliver accurate, meaningful insights at scale across advanced applications. In this session, attendees will learn how leading oncology institution, BC Cancer, transitioned to Illumina informatics to operationalize somatic variant interpretation, integrating an established workflow and knowledgebases while leveraging sophisticated curation capabilities to generate higher quality, more relevant findings at scale. Attendees will also get a preview of the latest innovations in Illumina informatics for key oncology applications including CGP, WGS analysis for hemopoietic disorders, and MRD detection.