As comprehensive genomic profiling (CGP) becomes a cornerstone of precision oncology research, an integrated and intelligent workflow is critical. SeqOne and Twist Bioscience have partnered to deliver an end-to-end solution combining the Twist Oncology DNA CGP Panel with the AI-powered SeqOne Analysis Platform. Twist's panel ensures high-quality variant detection, while SeqOne's platform, featuring the DiagAI engine, interprets complex data. DiagAI efficiently prioritizes clinically relevant alterations based on tumor type and evidence, reducing interpretation burden by focusing on actionable variants with full traceability. At AMP 2025, we will present performance data and use cases demonstrating how this joint workflow elevates the reliability and efficiency of molecular diagnostics, advancing precision medicine through trusted, AI-driven genomic analysis.