Assistant Professor MD Anderson Cancer Center Houston, Texas, United States
Description: In recent history, updated guidelines recommend germline genetic testing for all men with advanced prostate cancer regardless of family history, and somatic testing is also recommended with impacts on treatment selection- both standard of care and clinical trials. This has led to a significant increase in men needing genetic testing, and the MD Anderson Prostate Cancer Genetics Clinic has implemented video based education and consent processes for high throughput testing, as well as furthered research into germline-to-somatic relationships in prostate cancer that guide therapeutic selection. In this discussion, we will share our experience with integrated germline and somatic testing in men with prostate cancer as well as cascade testing and screening for unaffected men with germline mutations.
Learning Objectives: - Describe strategies for large scale, criteria-free germline testing in men with prostate cancer, as well as prevalence and penetrance of these gene mutations in men. - Describe impacts on treatment for both germline and somatic testing results in men with advanced prostate cancer.
