Associate Professor The Ohio State University Columbus, Ohio, United States
Description: Diagnosis and classification of splenic B cell lymphomas (SBL) are often challenging due to heterogenous, overlapping features and are further obscured by conflicting classification systems. Patients within the category of SBL include hairy cell leukemia (HCL), splenic diffuse red pulp lymphoma (SDRPL), splenic marginal zone lymphoma (SMZL), and HCL-variant (HCLv), which has recently been reassigned into the new WHO entity, splenic B cell lymphoma/leukemia with prominent nucleoli (SBLPN). In this presentation I will discuss the application of genome-wide DNA methylation profiling to perform unbiased molecular subclassification, revealing novel biological SBL subgroups with distinct pathobiological features.
Learning Objectives: - Describe novel splenic B cell lymphoma (SBL) entities revealed by DNA methylation profiling - Denomstrate how DNA methylation profiling can be used to refine the molecular classification of SBLs - Illustrate novel mechanisms of splenic B cell lymphomagenesis uncovered through the integration of epigenetic and other molecular features
